Endocrine Abstracts

People living with diabetes face the daily burden of managing their disease. The ongoing challenge of administering insulin, testing heir glucose and adhering to recommended lifestyle can be overwhelming. Diabetes technology can alleviate some of this burden. However, the technology should be chosen wisely upon preferences and competences of affected people. Insulin pump use has been increasing over the last decades. Insulin pumps re considered a comfortable way to deliver ins...

Introduction: In metformin-associated lactic acidosis with renal dysfunction inhibition of hepatic gluconeogenesis by drug accumulation may aggravate fasting induced-ketoacidosis. We report the occurrence of metformin-associated lactic acidosis with concurrent euglycemic ketoacidosis in three patients with renal failure.Cases: The first patient was a 79-year-old woman who suffered from chronic kidney disease stage IIIa after traumatic uninephrectomy, and...

Background: Permanent hypoparathyroidism is the most common complication of thyroid surgery with a reported incidence of 2-10% depending on the observation time, extent of surgery and underlying disease, with higher risk for total thyroidectomy and Graves disease/thyroid cancer. European data on chronic hypoparathyroidism have been reported from several countries, especially Scandinavia. We therefore aimed to add more information from Central Europe.Meth...

Introduction: Flash glucose monitoring (FGM) enables people with diabetes to regularly track their glucose levels without performing capillary finger-stick measurements (SMBG). Clinical studies have shown improvement in glycemic control, reduction of hypoglycemia, improvement in comfort and quality of life in people with type 1 diabetes (T1D) using this technology. In contrast to continuous glucose monitoring, FGM requires the performance of a scan to obtain the current glucos...

Introduction: Cytokines are produced in different tissues under physiological and pathophysiological conditions. The present study was performed to compare local concentrations of cytokines in subcutaneous adipose tissue and muscle using the open flow microperfusion (OFM) technique, as well as to investigate systemic effects of insulin on interstitial concentrations of these mediators.Methods: Ten healthy volunteers (age: 27±4 years, BMI: 22.6±...

Background and aims: Insulin therapy and the use of clinical decision support systems to achieve glycaemic control in hospitalized patients with hyperglycaemia are recommended by clinical guidelines. The aim of this evaluation was to assess time in target by continuous glucose monitoring (CGM) achieved by a basal-bolus insulin algorithm using insulin glargine U300 during hospital stay in patients with type 2 diabetes (T2D).Material and methods: 30 patien...

Introduction: Continuous glucose monitoring (CGM) has become an essential tool in diabetes management. In order to use CGM for treatment decisions, CGM systems have to be reliable over a wide range of glycemia as well as in situations with rapidly changing glucose levels such as exercise or in the postprandial state.Design: In this monocentric study we evaluated the performance of three commercially available CGM systems (Abbott Libre, Dexcom G4 Platinum...

Current guidelines recommend pre-meal blood glucose (BG) levels of <140 mg/dl in the hospital. The aim of this analysis was to compare two versions of a workflow-integrated algorithm for basal-bolus insulin therapy (REACTION algorithm) for glycemic management in patients with diabetes mellitus type 2 (T2D) hospitalized at the general ward.For both algorithms BG measurements were performed four times daily (pre-breakfast, pre-lunch, pre-dinner, and at...